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Hello everyone, how are you? My name is Samuel Dalle Laste, your doctor, and this is our space on the YouTube channel to talk about health, well-being and quality of life. Today I came here to talk to you about a very controversial topic, such as detox. Why did I decide to talk about it? And also because I realize that detox has become a very promising market. Today, you go to the supermarket and there are products that carry the name detox. And if you go to those stores that sell natural products, such as Mundo Verde, all in grains. These stores aim to deliver to you a more organic, more natural product among the industrialized products that these stores offer.
they sell well then maybe fifty percent will have the so-called detox there we see detox in drinks on food labels on cosmetic labels on shampoo absolutely everything carries the detox why because this has become a market people consumers they read detox they think like this I'm going to use this product because I'm going to get cleaner I'm going to get detoxified du and I think we have to understand what the so-called detox is to know where you can invest your money buying a product that carries this on the label or not right or if you're just spending money and often even consuming some industrialized product that although it has this name on the label it in addition to not bringing any benefit to your body it may have there in the ingredients some things that are not interesting to you so let's understand a little more about detox first that when I talk about detox and what organ comes to my mind like even put it here oh let's write here below liver hi samuel and the kidney kidney also participates in the detoxification process but very little maybe even less than 10 One hundred and ninety percent or more of the body's detoxification processes are via the liver. What is this detox process that happens in the liver? It's very simple, it's simpler than it seems. The body produces substances daily, produces neurotransmitters, hormones, in addition to what you produce, you also ingest things, right? We spend the day eating, ingesting liquid foods, but all of this has a hepatic metabolism process. Let's think like this: you took a medicine, I take medicine.
that you take and swallow, it is not even activated, it has to go through the liver to undergo the activation process that we call the first hepatic pass process, where it will pass through the liver, it will be activated and then it will start to take effect in the body, then it has a lifetime in the body and then it has to be deactivated because if it is not deactivated, it will not be able to be excreted, that is, it will not be eliminated from the body. And who is the organ that deactivates the liver again? So the liver activates and deactivates the drugs. Now, as an example, we talk about medicines, right? If you took dipyrone or paracetamol, it will reach your body. It will pass through the liver. The liver will activate it, then it will be made available in the tissues, right? It will go into the blood, into the tissue, and it will have its effect, and then the residue that will be left over from this returns to the liver. And the liver, through a detoxification process, will deactivate this drug so that it can be transformed into a metabolite that can be eliminated. It was clear. I used the example of the drug, but what the body itself produces, for example, a woman in the first phase of the menstrual cycle it will produce estrogen it will produce progesterone in the second phase these hormones that were not taken were not injected they were produced by the body itself they will have to undergo a detoxification process in the liver so that the liver can transform it into a metabolite that can be used otherwise the body cannot excrete the progesterone that will not come out ok I'm talking about pretty obvious things so far right there are some very bad things that the liver will also have to detoxify to eliminate like
organophosphates, which are part of the pesticide group, and substances such as dyes, preservatives, bisphenol-a, xenoestrogens, all extremely harmful things to the body that we come into contact with daily through environmental poisoning, through poor nutrition, this comes into contact with the body, and the liver has to be the organ that will metabolize all of this in order to detoxify it in order to write. Okay, so think about how much work this organ has to do. This liver organ has to do. Can it handle all of this? Look at the fig, a very strong organ. If you put an atomic bomb inside the movie, one day it will be able to handle all of this. It is a very strong organ. Only here we are living much longer. Before, when life expectancy was 37 to 40 years, you overloaded your child and he could handle it. Today we are living much longer, going past 70 years and the child will be two without it. Another thing that has also changed, besides the increase in life expectancy, is that today, for example, in Brazil, more than fifty people live longer. One hundred of the population has this increase in abdominal circumference, that is, they have some level of visceral fat inside the belly. Visceral fat is a term that is very important to understand when you are researching health. I made a video on YouTube. The link is here above so you can understand what visceral fat is. If you haven't watched this video, watch it all. Then go back to the fat that will be that fat that gets inside the belly around the viscera. One of the organs that is very susceptible to infiltration by visceral fat is the liver. So, think about it, as it is an organ that has to work whenever you eat junk food, whenever you are exposed to toxins and a bad diet, excessive alcohol consumption, excess toxins, and it will make you lose weight and fat inside the liver. So now you have a liver that the lens has to take care of itself.
of trying to create itself, right? Cleaning it, removing this fat from inside it. You have Finn, who has to do this work and on top of that, continue metabolizing the beer you drink or the pesticides you eat, the antinutrients you ingest. This organ will possibly cause problems. It won't be able to handle all of this until its last day of life, and then you start to have difficulty promoting the ideal detox of your body. And your body then starts to become intoxicated by Nutripur, by antinutrients, by metabolism, and they are not able to be excreted by the liver. Of course, it's complicated, and it will get a little more complicated when I talk about these little names. The liver has five stages of detoxification, one called glycerination, glucuronidation, sulfation, methylation, and acetylation. These are all liver detoxification processes. So when you do a detox diet, right? Let's do a detox diet protocol, which I do a lot here at the clinic with my patients. We use this term: a detox diet. Is that the food you are eating? It is a food that can detoxify you, of course not in any way. There is no detox diet. What exists is that you can do a diet for a period of time and obviously be on it for the rest of your life, where you cut out the intake of all the foods that will generate an overload for the body.
your liver, so if you want to do a detox diet, you need to eliminate foods with pesticides, so you will eat organic foods, you will eliminate transgenic foods that are highly inflammatory for the body, you will eliminate foods that require a little bit of the liver, right? Foods that are not liquid-type coffee, coffee is not very good for the liver, but coffee is not good, yes, coffee is good if your liver is fine, if you are clean, coffee is caffeine, an antioxidant, if consumed sensibly, it is good, but if your liver is not fine, coffee is also not good, so we eliminate from the diet everything that can overload the liver and we offer this patient a very natural diet where there is a diversity of nutrients, vitamins, minerals and trace elements that will help in this process because each of these processes is a process that depends on some nutrient, some amino acid, some cofactor, right, for example, the glycerination phase is a phase that its name already says, it depends on an amino acid called glycine, in this none of it has been very important, in fact it is very popular today because it is a of the amino acids it is the most important amino acid in the production of collagen so today everyone wants collagen there is a lot of talk about glycine because forty percent of collagen is formed by it teaches me only that it teaches you it actively participates in this miscegenation process the liver another place glucuronidation process what is the
The most important amino acid here is glutamic acid. Glutamic acid is essential for this detoxification pathway to occur. If this does not happen correctly, what is the problem? Well, there is a hormone that is very important for both men and women, which is the only hormone that detoxifies and is eliminated by the glucuronidation pathway, which is testosterone. So, if you eliminate this pathway, you deactivate it, you lyse testosterone. If you have an error in this cycle, you already have a huge problem. All the other steroid hormones include cortisol, androstenedione, progesterone, estrone, estradiol. All these other hormones are excreted and are deactivated by the sulfation pathway, which is a pathway that also does not work for free. The main amino acid in life that is sulfated is cysteine, cysteine, and here we also need selenium and vitamin B12. So, if you have a lack of cysteine, selenium B12, you already have difficulty detoxifying and eliminating some of them. And this is important. Don't think like that. Oh, wait a minute. If these hormones are good, I don't want to lose them, you produce hormones every minute, but you need to eliminate the hormone that has already done its job, that is, the hormone was produced, it went there
target tissue it played its role it came back as a metabolite now it needs to be eliminated so you need this right you don't want to keep everything for yourself right you need to eliminate well here I put the methylation phase in another color because I think all phases are equally important but methylation is my darling in the office and today I worry a lot about it because if I think about what is the disease that is the biggest cause of death in the world agents and it is still a heart attack in some countries it is already cancer but heart attack is still the biggest cause of death for many decades we attribute a heart attack to the consumption of fat increased cholesterol and what we did we gave the medicine to lower cholesterol to every patient in the office so to my patient with high cholesterol we gave her a little medicine to lower cholesterol and we thought that with that we were doing a great thing for the patient summary of the opera in 20 years the heart attack never decreased only a mentor it never stopped being the first cause of death in that is it only keeps lowering cholesterol obviously that is not what we have How to say the most important thing we have to do for our patient in the office is methylation. It is a cycle that involves an amino acid called methionine, hi, and the mind, nettion nina, and here it will go through some stages and methionine will convert into a byproduct called s-adenosyl methionine, which will convert into a byproduct called s-adenosyl homocysteine, which in turn will convert into a byproduct called homocysteine.
hi and homocysteine will convert into a byproduct called this action that will convert into a byproduct called cysteine so look I'm even going to put this cycle on the board here I'll put it here for you to look at it look it's quite confusing you see you don't even have to memorize and this is ok but it started with methionine ended with cysteine what's the importance of ending with cysteine well you just saw that without cysteine you don't have this phase your quote and cysteine it will join with glutamic acid oh and it will join with glycine hi and this this combination of these three peptides is what will form glutathione which is the largest before I count an hour and antioxidants of the body to work with free radical control oxidative stress so you need to have this phase very well functioning because you have to have the formation of cysteine it can't get stuck in the middle and what's the problem of getting stuck in the middle besides not having cysteine you have another problem which is homocysteine and why did I talk about heart attack because homocysteine today is considered the most depositing agent of fat in the arteries and it is the worst thing you can have in your body to increase the risk of heart attack, that is, everything we blamed on cholesterol and such, cholesterol and it only deposits in the artery forming a fat plaque if you have a place for it to deposit it does not stick to any artery there it only changes in the artery that allows this and high homocysteine is closely associated with this precipitation of cholesterol in the Samuel artery then
It's cool not to have homocysteine, not everything in life is a balance. Homocysteine has to be in a balance that goes from 5 to 8. We accept up to 10 as a tolerable limit, but not more than 10 because this is not good for the arteries. Homocysteine will only increase if you have an error in the phase. There are three enzymes here that do this methylation process. You can have an error in one of the enzymes, in two or even in three. These enzymes also have ugly names. If there is a stagnation reductase, there is one. If there is a stagnation synthetase, there is another. There is a third one called mthfr, methyl tetrahydrofolate reductase. What is the function of this enzyme? It will take folic acid and transform it into folate. We know that culturally pregnant women take folic acid before getting pregnant to properly close the neural tube of the fetus, and so on. Well, what we have seen in recent years is that many women, many do not, let's say that more and more women have the polymorphism result of this enzyme. mthfr there is a polymorphism, she does not convert folic acid into folate, so you are giving her folic acid but she is not using the folate, which is what really matters, and the enzymes here are already being proven that it can be associated with an increase in cases of autism, because when you give folic acid to a pregnant woman and she does not convert it into folate, she may be converting it into a product called a folate, this product is what increases the risk of autism, so it is also important. I have a practice of taking my patients who are going to get pregnant and I do a polymorphism test for this enzyme, which you can request, it is an extremely cheap test.
that you can find out whether you have this enzyme or not. It's interesting to know this, right? And then you want to see how everything is connected. The acetylation phase is an extremely important phase because if you have a failure in this phase, it is the phase that increases the probability of polymorphism. I'm talking about polymorphism, as everyone knows that's what it is, right? And in fact, it's complicated. Polymorphism is an error that you can inherit, where you have an enzyme that should work in one way and it works in the other, but you can inherit the polymorphism or you can acquire a polymorphism. For example, an error in the acetylation phase can cause a polymorphism. The first polymorph in history was a disease called sickle cell anemia. Sickle cell anemia is the typical example of a polymorph. Sickle cell anemia is very common. I don't remember the date here, but we know that sickle cell anemia has a higher prevalence in the black race. I have more sickle cell anemia, so I'm talking about a phase. An error in the acetylation phase can promote polymorphism. Hi, I'm done. to say that a polymorphism of this
enzyme that is increasingly common makes a mistake in the methylation phase. As you begin to understand, the human body is not isolated. All of this is interconnected. If one phase makes a mistake, the others are compromised. Shingles is the result. So, you have a whole orchestra happening in the liver. If you do not have an adequate diet, where you have given support from glycine, glutamic acid, cysteine, selenium, B12, here, too, in the methylation phase. I did not mention the three main ones here. It is getting so messy that I did not put them here. Look at the three main factors of the methylation phase. Here comes vitamin B12 again. Here comes vitamin B9, which is folic acid. And here comes vitamin B6, which is pyridoxal phosphate, pyridoxine. Look at the amount of nutrients that you make here that you need to have in order to do this.
how your liver performs the detoxification process and if you have any impairment here it will obviously have an impact on the pathology of the disease. We know that methylation, when an error occurs, if you increase homocysteine, in addition to increasing cardiac risk, as I already said, high homocysteine also greatly increases the risk of cancer and dementia. It's already written that dementia is caused by increased homocysteine. So diseases are never for nothing. They happen when there is an imbalance in some biochemical processes in the body and that these adjustments are associated with bad lifestyle habits. This is already clear to us. We know this. So how long are you going to stay there eating foods that ruin this mess and depriving yourself of eating truly natural foods that can offer a range of
nutrients to make this biochemical machinery work in a coherent way and in order to prevent diseases so maybe I'll even go too far off topic I'll come back here what is a detox process what is a detox diet it's not magic it's simply taking the individual remove everything that could compromise the health of the liver removes alcohol removes pesticides removes processed foods in boxes and packaged bags and offers a lot of nutritional load through a natural diet rich in nutrients to seek the balance of this liver along with this obviously if the patient has an excess of visceral fat we will make them lose weight the touch process they have to do physical activity they have to increase breathing
learning to breathe, doing diaphragmatic breathing techniques, all of this is important, right? Including doing a mental detox, as we know that we get very sick from contact with bad feelings, right? This process here, including that detox from toxic people, which we know there are many around us. Well, guys, the video is very long. I know I talked a lot about biochemistry here, but I also know that I read a lot of comments that you write below the videos and two or three people complain about this bunch of bad names, and the other, I don't know, a thousand people who write below say something cool. I'm learning a lot, so I'm putting it here because that way you don't have to memorize these names, but you can understand how it all works. If you like biochemistry, then that's it.
Here, this chart is practically the summary of the detox. Ok, good, and it's also important to understand that I don't want anyone to do the detox process or detox diet on their own. Every individual needs to have a professional who takes care of their diet, and this is called a nutritionist. Obviously, look for a qualified nutritionist. We know that today, there are very few nutritionists who really work with nutrigenomics. Most work with diets to lose weight, diets counting calories. Look for a professional who works with epigenetics and nutrigenomics. Here's a tip. I hope you liked the video. If you liked it, share it. Click here and subscribe. Below the video, there's a link where you can be part of a VIP group that will receive exclusive content from our channel. Thanks a lot.
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